Ph.D. BSc(Hons), PGCert
University Research Lecturer
- Wellcome Trust/Royal Society Sir Henry Dale Fellow
- NIHR Oxford BRC Senior Fellow
I am a Population Health Scientist interested in better understanding the benefits and harms of treatments, with a particular focus on cardiovascular disease prevention. My research aims to develop tools which improve the targeting of preventative therapies such as antihypertensives and statins at patients with the most to gain.
I lead the Stratified TreAtments Research (STAR) Group which uses data from routine electronic health records to better understand the association between treatment and harms. Our work uses prognostic modelling techniques to predict those patients who are most likely to benefit and those most likely to suffer harm from these treatments. We also undertake systematic reviews of adverse events associated with treatment and randomised controlled trials of targeted deprescribing in older patients, including the OPTiMISE trial.
My previous work has involved developing a clinical prediction tool for PRedicting Out-of-OFfice Blood Pressure (PROOF-BP) to enable targeting of ambulatory blood pressure monitoring in primary care. I teach on the Evidence Based Medicine MSc degree programme, am deputy for the departments’ Athena Swan initiative and am recent past Chair of the British and Irish Hypertension Society Young Investigator Network.
Effect of antihypertensive medication reduction vs usual care on short-term blood pressure control in patients aged ≥ 80 years with hypertension The OPTiMISE randomized clinical trial
MCMANUS R. and SHEPPARD J., (2020), JAMA: Journal of the American Medical Association
Benefits and harms of antihypertensive treatment for low risk mild hypertension: a real world, matched cohort study of over 38,000 adults
Sheppard JP. et al, (2018), JAMA Internal Medicine
Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: an observational cohort study
Sheppard JP. et al, BMJ
Tucker KL. et al, (2017), PLoS medicine, 14, e1002389 - e1002389
de Lusignan S. et al, (2020), J Infect