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One of the major problems related to cancer treatment is its recurrence. Without knowing in advance how likely the cancer will relapse, clinical practice usually recommends adjuvant treatments that have strong side effects. A way to optimize treatments is to predict the recurrence probability by analyzing a set of bio-markers. The NeoMark European project has identified a set of preliminary bio-markers for the case of oral cancer by collecting a large series of data from genomic, imaging, and clinical evidence. This heterogeneous set of data needs a proper representation in order to be stored, computed, and communicated efficiently. Ontologies are often considered the proper mean to integrate biomedical data, for their high level of formality and for the need of interoperable, universally accepted models. This paper presents the NeoMark system and how an ontology has been designed to integrate all its heterogeneous data. The system has been validated in a pilot in which data will populate the ontology and will be made public for further research.

Original publication

DOI

10.1109/TBME.2012.2216879

Type

Journal article

Journal

IEEE Trans Biomed Eng

Publication Date

01/2013

Volume

60

Pages

216 - 220

Keywords

Biomarkers, Tumor, Computational Biology, Diagnosis, Computer-Assisted, Humans, Models, Statistical, Mouth Neoplasms, Neoplasm Recurrence, Local, Reproducibility of Results