This report presents the results of a systematic review and meta-analyses of studies on epithelium-off photochemical corneal collagen cross-linkage for the management of keratoconus and secondary ectasia. The literature search identified 3,400 records of which 49 were considered for inclusion in the meta-analyses. Eight papers reported 4 unique randomized controlled trials, 29 studies were prospective, and 12 were retrospective studies. The majority of the studies (39/49) were graded as very low quality evidence. Twenty-six studies described adverse events and were included in the safety analysis. Meta-analyses are presented for changes in four outcomes: visual acuity, topography, refraction and astigmatism, and central corneal thickness. Statistically significant improvements were found in all efficacy outcomes at 12 months after the operation. Common side effects were pain, corneal edema, and corneal haze, which resolved usually within a few days after the procedure. The remaining uncertainty is duration of benefit to establish the procedure's potential benefit in avoiding or delaying disease progression and possibly reducing the need for corneal transplantation.

Original publication

DOI

10.1016/j.jtos.2014.05.002

Type

Journal article

Journal

Ocul Surf

Publication Date

07/2014

Volume

12

Pages

202 - 214

Keywords

epithelium-off collagen cross-linkage, keratectasia, keratoconus, meta-analysis, systematic review, Collagen, Corneal Stroma, Cross-Linking Reagents, Humans, Keratoconus, Photosensitizing Agents, Riboflavin, Ultraviolet Rays, Ultraviolet Therapy