Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors that activate a number of hypoxia responsive genes, some of which are responsible for protective cellular functions. During organ donation, allografts are exposed to significant periods of hypoxia and ischemia. Exploiting this pathway during donor management and organ preservation could prevent and reduce allograft injury and improve the outcomes of organ transplantation. We review the evidence on this pathway in organ preservation, drawing on experimental studies on donor management and ischemia reperfusion injury focusing on kidney, liver, cardiac and lung transplantation. We review the major technical and experimental challenges in exploring this pathway and suggest potential future avenues for research.

Original publication

DOI

10.1111/ajt.12737

Type

Journal article

Journal

Am J Transplant

Publication Date

07/2014

Volume

14

Pages

1481 - 1487

Keywords

HIF, hypoxia, ischemia, ischemia reperfusion injury, transplant, Humans, Hypoxia, Hypoxia-Inducible Factor 1, Organ Preservation, Organ Transplantation, Reperfusion Injury, Tissue and Organ Procurement