The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

Original publication

DOI

10.1038/35102112

Type

Journal article

Journal

Nature

Publication Date

01/11/2001

Volume

414

Pages

34 - 35

Keywords

Adipose Tissue, Adult, Biological Evolution, Body Mass Index, Energy Metabolism, Female, Frameshift Mutation, Heterozygote, Humans, Leptin, Male, Middle Aged, Obesity