Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.

Type

Journal article

Journal

Breast Cancer Res

Publication Date

2001

Volume

3

Pages

313 - 317

Keywords

Breast, Breast Neoplasms, DNA-Binding Proteins, Female, Humans, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Neovascularization, Pathologic, Nuclear Proteins, Oxidative Stress, Signal Transduction, Transcription Factors