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Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

17/04/2003

Volume

13

Pages

1451 - 1454

Keywords

Aminobutyrates, Animals, Autoradiography, Binding Sites, Enzyme Inhibitors, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Iron, Isoenzymes, Procollagen-Proline Dioxygenase, Transcription Factors, Tumor Suppressor Proteins