Sperm dysfunction is the single most common defined cause of infertility. One in 15 men is sub-fertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment. The reason for this is our limited understanding of the biochemical, molecular and genetic functions of the spermatozoon. The underlying premise of our research programme is to establish a rudimentary understanding of the processes necessary for successful fertilisation. In this manuscript, we detail advances in our understanding of calcium signalling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.

Type

Journal article

Journal

Soc Reprod Fertil Suppl

Publication Date

2007

Volume

63

Pages

237 - 255

Keywords

Calcium, Calcium Signaling, Humans, Infertility, Male, Male, Proteomics, Sodium-Calcium Exchanger, Spermatozoa