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Hypoxia-inducible factor (HIF) is a family of transcription factors that regulate the homeostatic response to oxygen deprivation during development, physiological adaptation, and pathological processes such as ischemia and neoplasia. Our understanding of the function of different HIF isoforms is being advanced by understanding the processes that regulate their activity, learning where and when they are expressed and what genes they regulate.

Original publication

DOI

10.1038/sj.ki.5000072

Type

Journal article

Journal

Kidney Int

Publication Date

01/2006

Volume

69

Pages

15 - 17

Keywords

Animals, Basic Helix-Loop-Helix Transcription Factors, Gene Expression Regulation, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Kidney Neoplasms