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The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF alpha subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenvironmental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours.

Type

Journal article

Journal

Curr Opin Genet Dev

Publication Date

06/2001

Volume

11

Pages

293 - 299

Keywords

Animals, Basic Helix-Loop-Helix Transcription Factors, DNA-Binding Proteins, Humans, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Neoplasms, Nuclear Proteins, Signal Transduction, Trans-Activators, Transcription Factors