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NIHR CLAHRC-funded researchers lead unique BBC experiment investigating tailoring diets for weight loss.

Left to right: Susan Jebb, Fiona Gribble, Paul Aveyard, Chris Van Tulleken, Tanya Byron and Giles Yeo. © BBC
Left to right: Susan Jebb, Fiona Gribble, Paul Aveyard, Chris Van Tulleken, Tanya Byron and Giles Yeo.

In a 3-part Horizon special, BBC Science, together with Britain’s leading obesity researchers, will investigate three different causes of overeating and how a weight loss programme tailored to each of these causes can help people to lose weight. 

In Britain today 11 million people are on a diet - yet the vast majority of them will fail to control their weight in the long term. 

Most diets are a one-size-fits-all approach. But each of us puts on weight for different reasons and scientists are currently investigating how differences in our biochemistry, psychology and our genes affect our weight. 

In a ground-breaking national experiment - the first of its kind - Dr Chris Van Tulleken and clinical psychologist Professor Tanya Byron, together with Britain’s foremost diet and obesity scientists from Oxford and Cambridge universities, test how helping people to understand their biology and their psychology and tailoring the weight loss plans to combat these characteristics can help people lose weight. They’ve selected 75 overweight volunteers from across the UK whose weight loss programme will be tailored to explore three particular causes of overeating: genes, gut hormones, and emotion-related eating.

Packed full of new research on the causes of obesity, demonstrations, tips for weight loss and general dietary advice, the programme offers credible, useful information for everyone as it follows the experience of the three groups of dieters.

This unique television experiment is led by a team of world-class scientists from the Nuffield Department of Primary Care Health Sciences at the University of Oxford, and the Department of Clinical Biochemistry at the University of Cambridge:

Susan Jebb – Professor of Diet and Population Health, University of Oxford
Paul Aveyard – GP and Professor of Behavioural Medicine, University of Oxford
Dr Giles Yeo – Geneticist, University of Cambridge
Fiona Gribble – Professor of Endocrine Physiology, University of Cambridge.

The researchers put 75 overweight volunteers through a series of tests to find out why they eat too much and are overweight. The volunteers are divided into three groups, each based on different reasons for over eating:

  • Feasters - produce less of a gut hormone which tells them when to stop eating so they don’t realise when they are full.
  • Constant Cravers – have ‘hungry’ genes that increase their risk of obesity and can make them feel hungry all the time.
  • Emotional Eaters - eat in response to negative feelings, such as unhappiness or stress.

Each group is guided to follow a diet tailored to address the causes of their overeating and the scientists track their progress over three months. In a series of experiments the participants learn more about the causes of their overeating and how by changing the type of food they eat or their eating behaviour they can all lose weight.

Viewers at home can also find out which diet might be right for them by trying the online diet test, available along with the eBook from January 12 at

OxFAB - an online study 

To accompany the BBC series, National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) Oxford-funded DPhil student Jamie Hartmann-Boyce is launching an online study to consider the behaviours people use to manage their weight. Aimed at people trying to lose weight through diet and/or exercise, the study asks a series of questions about the types of strategies used to loose weight, and encourages participants to answer questions twice a week over a three-month period.

Find out more at 

“What’s the right diet for you: A Horizon Special” airs at 9pm on BBC Two - 12, 13 and 14 January 2015.

Take part in a study


How do you lose weight? Take part in our own online experiment to accompany the series and help us find out what strategies people use to manage their weight.